Is Related to Prolonged Survival in Sickle Cell Anemia
نویسندگان
چکیده
We have determined the frequency of deletional a-thalassemia in black populations in the USA and Africa that harbor sickle cell anemia. In normals. the frequency of the chromosome bearing a deletion of one of the two normal a gene loci. designated ( -a). ranged from 0.12 to 0.16, and in sickle trait subjects. the frequency ranged from 0.1 8 to 0.20. By contrast. in sickle cell anemia subjects. the frequency was significantly greater and ranged from 0.22 to 0.33. Analysis demonstrated that the greater frequency
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متن کاملAlpha-thalassemia is related to prolonged survival in sickle cell anemia.
We have determined the frequency of deletional alpha-thalassemia in black populations in the USA and Africa that harbor sickle cell anemia. In normals, the frequency of the chromosome bearing a deletion of one of the two normal alpha gene loci, designated (-alpha), ranged from 0.12 to 0.16, and in sickle trait subjects, the frequency ranged from 0.18 to 0.20. By contrast, in sickle cell anemia ...
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